Abstract: Changing Zn/Sr molar ratio and hydrothermal reaction time of the reaction solution,the strontium and zinc substituted hydroxyapatite (Zn-Sr-HA) microspheres were successfully prepared via hydrothermal method.The structure,composition and morphology of microspheres were studied by optical microscopy,X-ray fluorescence spectrometry (XRF),X-ray diffraction (XRD) and field emission scanning electron microscope (SEM).The results show that the products are all composed of HA microspheres when the Zn/Sr molar ratio is 3:2 or 1:1 in the initial solution at reaction temperature 180℃ for 3 h to 4 h.The average diameter of microspheres is about 10 μm to 20 μm,with uniform size and good dispersion.With the increase of the molar ratio of Zn/Sr in the initial solution,the Zn/Sr molar ratio of HA microspheres increase gradually,and the cell parameters a and c values decrease gradually.

Key words: Changing Zn/Sr molar ratio and hydrothermal reaction time of the reaction solution,the strontium and zinc substituted hydroxyapatite (Zn-Sr-HA) microspheres were successfully prepared via hydrothermal method.The structure,composition and morphology of microspheres were studied by optical microscopy,X-ray fluorescence spectrometry (XRF),X-ray diffraction (XRD) and field emission scanning electron microscope (SEM).The results show that the products are all composed of HA microspheres when the Zn/Sr molar ratio is 3:2 or 1:1 in the initial solution at reaction temperature 180℃ for 3 h to 4 h.The average diameter of microspheres is about 10 μm to 20 μm,with uniform size and good dispersion.With the increase of the molar ratio of Zn/Sr in the initial solution,the Zn/Sr molar ratio of HA microspheres increase gradually,and the cell parameters a and c values decrease gradually.