Synthesis, Crystal Growth and Photodynamic Antibacterial Activity of Monohydroxy Corrole

Abstract

Abstract: Photodynamic antimicrobial therapy (PDAT) is a new method for the treatment of microbial infections. However, there have been few reports on the photodynamic antimicrobial activity of corrole, which has a significant advantage in the treatment of photodynamic antitumor activity. In this study, mono-hydroxyl corrole named 10-(4-hydroxyphenyl)-5,15-bis(pentafluorophenyl) corrole (P-OH) was synthesized. What’s more, its crystal structure and photodynamic antibacterial activity were also explored. The results indicate that mono-hydroxyl corrole belongs to orthorhombic crystal system and shows good photodynamic antibacterial activity. When the concentration of the drug is more than 2MIC, the bacteriostatic effect is showed. Whereas, the concentration of drug less than 2MIC shows antibacterial effect. The minimum bactericidal concentration and minimum inhibitory concentration of the drug are lower than porphyrin, it is a good photodynamic antibacterial photosensitizer.

Key words: corrole, mono-hydroxyl corrole, synthesis, crystal structure, photodynamic antimicrobial therapy

CLC Number:

O641.4

WU Shuqiong, HE Yuliang, ZHENG Jiaqi, HUANG Wanyu, CHEN Peini, MO Xiaolin, YE Jiaxin, OU Xiaoqian, LIN Jiaying, GUO Huilin, HUANG Huilin, XU Yige, SHI Lei, SHE Tingting, ZHONG Yonghui. Synthesis, Crystal Growth and Photodynamic Antibacterial Activity of Monohydroxy Corrole[J]. Journal of Synthetic Crystals, 2023, 52(3): 510-519.

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