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人工晶体学报 ›› 2021, Vol. 50 ›› Issue (11): 2103-2108.

• 研究论文 • 上一篇    下一篇

一种多吡啶铜(Ⅰ)配合物的合成、结构及DNA光裂解研究

张琴, 黄羽, 李知敏, 胡迈, 廖向文, 王金涛   

  1. 江西科技师范大学药学院,江西省药物分子设计与评价重点实验室,南昌 330013
  • 出版日期:2021-11-15 发布日期:2021-12-13
  • 通讯作者: 廖向文,博士,讲师。E-mail:liao492008522@163.com; 王金涛,博士,副教授。E-mail:jintaochem@163.com
  • 作者简介:张 琴(1995—),女,四川省人,硕士研究生。E-mail:1217094965@qq.com
  • 基金资助:
    国家自然科学基金(22067007,22067006);江西科技师范大学大学生创新训练计划(20201404122)

Synthesis, Structure and DNA Photocleavage of a Polypyridine Copper(Ⅰ) Complex

ZHANG Qin, HUANG Yu, LI Zhimin, HU Mai, LIAO Xiangwen, WANG Jintao   

  1. Jiangxi Provincial Key Laboratory of Drug Design and Evalution, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China
  • Online:2021-11-15 Published:2021-12-13

摘要: 本文以1-甲基-4′-对苯甲基-2,2′,6′,2″-三联吡啶六氟磷酸盐(L)为配体合成了一例新的铜配合物[CuL2](PF6)3·H2O(配合物1)。通过X射线单晶衍射技术、热重分析和X射线光电子能谱(XPS)对所合成的配合物进行了结构的表征和化学价的分析。单晶衍射分析结果表明,该配合物属于单斜晶系,P21/c空间群,晶胞参数为a=1.273 15(10) nm、b=1.902 01(13) nm、c=2.109 55(17) nm、β=101.269(2)°、V=5.009 9(7) nm3。XPS分析结果表明,配合物中的铜离子是以+1价的形式存在。热重分析表明,该配合物具有较高的热稳定性。琼脂糖凝胶电泳实验表明,该配合物在光照条件下能有效使DNA裂解,表明该配合物具有明显的潜在生物活性。

关键词: 多吡啶, 铜配合物, 溶剂慢挥发法, 凝胶电泳实验, DNA光裂解

Abstract: In this paper, a copper complex [CuL2](PF6)3·H2O(complex 1) was synthesized using 1-methyl-4′-(p-tolyl)-2,2′,6′,2″-terpyridine hexafluorophosphate (L) as the ligand. The structure of the synthesized complex was characterized by X-ray single crystal diffraction technique, thermogravimetric analysis and X-ray photoelectron spectroscopy (XPS). The results of single crystal diffraction analysis show that the complex belongs to the monoclinic crystal system, the P1/c space group, and the unit cell parameters were a=1.273 15(10) nm, b=1.902 01(13) nm, c=2.109 55(17) nm, β=101.269(2)° and V=5.009 9(7) nm3. The XPS analysis result shows that the copper ions in complex 1 exists in the form of +1 valence. Thermogravimetric analysis shows that the complex has good thermal stability. DNA photocleavage studies monitored by agarose gel electrophoresis shows that the complex cleaved DNA efficiently, which indicates that the complex has obvious potential biological activity.

Key words: polypyridine, copper complex, slow solvent evaporation, agarose gel electrophoresis, DNA photocleavage

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