Amino Acids/Graphene Oxide/Hydroxyapatite Composites on in vitro Remineralization of Acid-Etched Human Enamel

Abstract

Abstract: Effects of glycine (Gly) and graphene oxide (GO) modified hydroxyapatite (Gly/GO/HA), and aspartic acid (Asp) and GO modified hydroxyapatite (Asp/GO/HA) on in vitro remineralization of acid-etched human enamel (HE) were investigated. The cytotoxicity of these composites was studied by CCK-8 method, the surface and cross-section morphology, surface element composition, surface composition structure and surface mechanical properties of HE before and after remineralization were characterized by field emission scanning electron microscope, EDX energy spectrum analysis, X-ray diffraction and microhardness test. The results show that Gly/GO/HA and Asp/GO/HA both have good safety and biocompatibility, and both can repair the acid-etched HE to a certain extent, among which Gly/GO/HA is better than Asp/GO/HA in repairing the surface and deep demineralization of the acid-etched HE.

Key words: amino acid, graphene oxide, hydroxyapatite, enamel, remineralization, cytotoxicity

CLC Number:

CAI Ying, CHUAN Dingze, CHEN Qinghua, LIU Jitao. Amino Acids/Graphene Oxide/Hydroxyapatite Composites on in vitro Remineralization of Acid-Etched Human Enamel[J]. JOURNAL OF SYNTHETIC CRYSTALS, 2022, 51(3): 516-522.

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