基于介孔二氧化硅包载白藜芦醇纳米体系的制备

摘要/Abstract

摘要： 本实验旨在构建一种介孔二氧化硅包载白藜芦醇的纳米体系,并通过扫描电子显微镜、透射电子显微镜、X射线衍射、N₂ 吸附-脱附、差热-热重分析等对包载白藜芦醇前后的纳米体系进行表征分析,探究其光、热稳定特性和体外不同pH 值缓冲液中的释放规律。结果表明,制备的介孔二氧化硅包载白藜芦醇纳米体系,其骨架呈交联网络结构,孔径、比表面积和孔容分别为10.16 nm、245.73 m²/g和0.79 cm³/g,负载量可达39.44%,且负载后其骨架结构未破坏,并有效提高了白藜芦醇的光、热稳定性。同时,经过纳米体系负载后的白藜芦醇2 h内释放速率在两种不同pH 值缓冲液中均可达80%以上。介孔二氧化硅包载白藜芦醇纳米体系性能较好,为白藜芦醇的进一步开发利用提供参考。

关键词: 白藜芦醇, 介孔二氧化硅, 纳米传递系统, 载药量, 释放速率, 稳定性

Abstract: The purpose of this experiment was to construct a mesoporous silicon-encapsulated resveratrol nano-delivery system. The nanosystem before and after loading resveratrol was characterized and analyzed by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, N₂ adsorption-desorption, differential thermal-thermogravimetric analysis. Its light and heat stability properties and release laws in different pH buffers in vitro were explored. The results show that the mesoporous silica-encapsulated resveratrol nano-delivery system has a cross-linked network structure. The pore size, specific surface area and pore volume are 10.16 nm, 245.73 m²/g and 0.79 cm³/g, respectively, and the loading capacity could reach 39.44%. The framework structure is not destroyed after loading, and the optical and thermal stability of resveratrol is effectively improved. Meanwhile, the release rate of resveratrol after nanosystem loading is more than 80% within 2 h in two different pH buffers. The mesoporous silica-encapsulated resveratrol nanosystem has better performance and provides reference significance for the further development and utilization of resveratrol.

Key words: resveratrol, mesoporous silica, nano-delivery system, drug loading capacity, release rate, stability

中图分类号:

TQ460.4

张文君, 李想, 张国锋, 王晴, 吕春艳, 刘杨. 基于介孔二氧化硅包载白藜芦醇纳米体系的制备[J]. 人工晶体学报, 2021, 50(12): 2323-2331.

ZHANG Wenjun, LI Xiang, ZHANG Guofeng, WANG Qing, LYU Chunyan, LIU Yang. Preparation of Resveratrol Nano-Delivery System Based on Mesoporous Silica[J]. JOURNAL OF SYNTHETIC CRYSTALS, 2021, 50(12): 2323-2331.

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