单羟基咔咯的合成、晶体的生长和光动力抗菌活性研究

人工晶体学报 ›› 2023, Vol. 52 ›› Issue (3): 510-519.

单羟基咔咯的合成、晶体的生长和光动力抗菌活性研究

吴淑琼¹, 何裕良¹, 郑嘉琪¹, 黄婉瑜¹, 陈培妮², 莫晓琳², 叶嘉欣¹, 欧晓倩¹, 林佳颖¹, 郭惠琳¹, 黄慧琳¹, 许逸戈¹, 史蕾¹, 佘婷婷², 钟永辉³

1.广东第二师范学院化学与材料科学学院,广州 510800;
2.广东第二师范学院生物与食品工程学院,广州 510303;
3.佛山市第四人民医院结核科,佛山 528041

收稿日期:2022-10-31 出版日期:2023-03-15 发布日期:2023-04-06
通信作者: 史蕾,博士,副教授。E-mail:shil@gdei.edu.cn
佘婷婷,实验师。E-mail:359780069@qq.com
钟永辉,主任医师。E-mail:275237077@qq.com
作者简介:吴淑琼(1998—),女,广东省人。E-mail:wushuqiong120@qq.com
基金资助:
佛山市第四人民医院“登峰计划”高水平医院建设开放课题项目(FSSYKF2020012);广东省高等学校教学管理学会2021年度课程思政建设项目(X-KCSZ2021143);广东省科技创新战略专项资金(pdjh2023b0387,pdjh2021b0370);大学生创新创业训练计划项目(202214278008,202214278094X)

Synthesis, Crystal Growth and Photodynamic Antibacterial Activity of Monohydroxy Corrole

WU Shuqiong¹, HE Yuliang¹, ZHENG Jiaqi¹, HUANG Wanyu¹, CHEN Peini², MO Xiaolin², YE Jiaxin¹, OU Xiaoqian¹, LIN Jiaying¹, GUO Huilin¹, HUANG Huilin¹, XU Yige¹, SHI Lei¹, SHE Tingting², ZHONG Yonghui³

1. Department of Chemistry and Materials Science, Guangdong University of Education, Guangzhou 510800, China;
2. Department of Biological Food Engineering, Guangdong University of Education, Guangzhou 510303, China;
3. Department of Laboratory Medicine Foshan Forth People's Hospital, Foshan 528041, China

Received:2022-10-31 Online:2023-03-15 Published:2023-04-06

摘要/Abstract

摘要： 光动力抗菌疗法(PDAT)是一种新型的治疗微生物感染的手段,咔咯在光动力抗肿瘤方面具有显著优势,但在光动力抗菌方面却鲜有报道。本文合成了单羟基咔咯即10-(4-羟基苯基)-5,15-二(2,3,4,5,6-五氟苯基)咔咯(P-OH),并进一步研究其晶体结构和光动力抗菌活性。结果表明,单羟基咔咯属于正交晶系,具有良好的光动力抗菌活性,药物浓度大于2MIC时其显示出杀菌作用,药物浓度小于2MIC时其显示出抑菌作用,其最低杀菌浓度和最低抑菌浓度皆比卟啉低,是一种良好的光动力抗菌光敏剂。

关键词: 咔咯, 单羟基咔咯, 合成, 晶体结构, 光动力抗菌疗法

Abstract: Photodynamic antimicrobial therapy (PDAT) is a new method for the treatment of microbial infections. However, there have been few reports on the photodynamic antimicrobial activity of corrole, which has a significant advantage in the treatment of photodynamic antitumor activity. In this study, mono-hydroxyl corrole named 10-(4-hydroxyphenyl)-5,15-bis(pentafluorophenyl) corrole (P-OH) was synthesized. What’s more, its crystal structure and photodynamic antibacterial activity were also explored. The results indicate that mono-hydroxyl corrole belongs to orthorhombic crystal system and shows good photodynamic antibacterial activity. When the concentration of the drug is more than 2MIC, the bacteriostatic effect is showed. Whereas, the concentration of drug less than 2MIC shows antibacterial effect. The minimum bactericidal concentration and minimum inhibitory concentration of the drug are lower than porphyrin, it is a good photodynamic antibacterial photosensitizer.

Key words: corrole, mono-hydroxyl corrole, synthesis, crystal structure, photodynamic antimicrobial therapy

中图分类号:

O641.4

吴淑琼, 何裕良, 郑嘉琪, 黄婉瑜, 陈培妮, 莫晓琳, 叶嘉欣, 欧晓倩, 林佳颖, 郭惠琳, 黄慧琳, 许逸戈, 史蕾, 佘婷婷, 钟永辉. 单羟基咔咯的合成、晶体的生长和光动力抗菌活性研究[J]. 人工晶体学报, 2023, 52(3): 510-519.

WU Shuqiong, HE Yuliang, ZHENG Jiaqi, HUANG Wanyu, CHEN Peini, MO Xiaolin, YE Jiaxin, OU Xiaoqian, LIN Jiaying, GUO Huilin, HUANG Huilin, XU Yige, SHI Lei, SHE Tingting, ZHONG Yonghui. Synthesis, Crystal Growth and Photodynamic Antibacterial Activity of Monohydroxy Corrole[J]. JOURNAL OF SYNTHETIC CRYSTALS, 2023, 52(3): 510-519.

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