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人工晶体学报 ›› 2023, Vol. 52 ›› Issue (3): 510-519.

• 研究论文 • 上一篇    下一篇

单羟基咔咯的合成、晶体的生长和光动力抗菌活性研究

吴淑琼1, 何裕良1, 郑嘉琪1, 黄婉瑜1, 陈培妮2, 莫晓琳2, 叶嘉欣1, 欧晓倩1, 林佳颖1, 郭惠琳1, 黄慧琳1, 许逸戈1, 史蕾1, 佘婷婷2, 钟永辉3   

  1. 1.广东第二师范学院化学与材料科学学院,广州 510800;
    2.广东第二师范学院生物与食品工程学院,广州 510303;
    3.佛山市第四人民医院结核科,佛山 528041
  • 收稿日期:2022-10-31 出版日期:2023-03-15 发布日期:2023-04-06
  • 通信作者: 史 蕾,博士,副教授。E-mail:shil@gdei.edu.cn
    佘婷婷,实验师。E-mail:359780069@qq.com
    钟永辉,主任医师。E-mail:275237077@qq.com
  • 作者简介:吴淑琼(1998—),女,广东省人。E-mail:wushuqiong120@qq.com
  • 基金资助:
    佛山市第四人民医院“登峰计划”高水平医院建设开放课题项目(FSSYKF2020012);广东省高等学校教学管理学会2021年度课程思政建设项目(X-KCSZ2021143);广东省科技创新战略专项资金(pdjh2023b0387,pdjh2021b0370);大学生创新创业训练计划项目(202214278008,202214278094X)

Synthesis, Crystal Growth and Photodynamic Antibacterial Activity of Monohydroxy Corrole

WU Shuqiong1, HE Yuliang1, ZHENG Jiaqi1, HUANG Wanyu1, CHEN Peini2, MO Xiaolin2, YE Jiaxin1, OU Xiaoqian1, LIN Jiaying1, GUO Huilin1, HUANG Huilin1, XU Yige1, SHI Lei1, SHE Tingting2, ZHONG Yonghui3   

  1. 1. Department of Chemistry and Materials Science, Guangdong University of Education, Guangzhou 510800, China;
    2. Department of Biological Food Engineering, Guangdong University of Education, Guangzhou 510303, China;
    3. Department of Laboratory Medicine Foshan Forth People's Hospital, Foshan 528041, China
  • Received:2022-10-31 Online:2023-03-15 Published:2023-04-06

摘要: 光动力抗菌疗法(PDAT)是一种新型的治疗微生物感染的手段,咔咯在光动力抗肿瘤方面具有显著优势,但在光动力抗菌方面却鲜有报道。本文合成了单羟基咔咯即10-(4-羟基苯基)-5,15-二(2,3,4,5,6-五氟苯基)咔咯(P-OH),并进一步研究其晶体结构和光动力抗菌活性。结果表明,单羟基咔咯属于正交晶系,具有良好的光动力抗菌活性,药物浓度大于2MIC时其显示出杀菌作用,药物浓度小于2MIC时其显示出抑菌作用,其最低杀菌浓度和最低抑菌浓度皆比卟啉低,是一种良好的光动力抗菌光敏剂。

关键词: 咔咯, 单羟基咔咯, 合成, 晶体结构, 光动力抗菌疗法

Abstract: Photodynamic antimicrobial therapy (PDAT) is a new method for the treatment of microbial infections. However, there have been few reports on the photodynamic antimicrobial activity of corrole, which has a significant advantage in the treatment of photodynamic antitumor activity. In this study, mono-hydroxyl corrole named 10-(4-hydroxyphenyl)-5,15-bis(pentafluorophenyl) corrole (P-OH) was synthesized. What’s more, its crystal structure and photodynamic antibacterial activity were also explored. The results indicate that mono-hydroxyl corrole belongs to orthorhombic crystal system and shows good photodynamic antibacterial activity. When the concentration of the drug is more than 2MIC, the bacteriostatic effect is showed. Whereas, the concentration of drug less than 2MIC shows antibacterial effect. The minimum bactericidal concentration and minimum inhibitory concentration of the drug are lower than porphyrin, it is a good photodynamic antibacterial photosensitizer.

Key words: corrole, mono-hydroxyl corrole, synthesis, crystal structure, photodynamic antimicrobial therapy

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