水热釜填充度与溶液pH值对水热法制备钙磷涂层的影响

摘要/Abstract

摘要： 本文以CaCl₂与KH₂PO₄为原料,Na₂EDTA·2H₂O为螯合剂,通过NH₃·H₂O调节溶液pH值,系统研究了水热釜填充度(16%~64%)与溶液pH值(3.5~6.0)对水热法制备钛表面钙磷涂层形貌和物相的影响。结果表明:当pH值为3.5和4.0时,涂层在所研究填充度的范围内主要为三斜结构(P1)的板块状磷酸氢钙(DCPA);当pH值为4.5和5.0时,低填充度有利于形成六方结构(P6₃/m)的蒲公英状羟基磷灰石(HAP),并随填充度的提高,涂层由蒲公英状HAP逐渐转变为板块状DCPA;当pH值为5.5和6.0时,涂层在所研究填充度的范围内主要为蒲公英状HAP,HAP的结晶度随填充度的提高逐渐增加,而随pH值的升高蒲公英状HAP的直径逐渐减小。另外,本文获得的单相HAP涂层、单相DCPA涂层和(HAP+DCPA)两相混合涂层的润湿性均显著优于钛表面,这将有助于植体的骨整合。同时,本文也探究了不同钙磷涂层的反应机理。

关键词: 钙磷涂层, 羟基磷灰石, 磷酸氢钙, 水热法, 填充度, pH值, 润湿性

Abstract: In this paper, CaCl₂ and KH₂PO₄ were used as raw materials, Na₂EDTA·2H₂O as chelating agent, and NH₃·H₂O was used to adjust pH value of the solution, the calcium-phosphate coatings on titanium substrate were prepared via hydrothermal method, and the effects of filling condition (FC) (16%~64%) and pH value (3.5~6.0) on morphology and phase constitutions of the coatings were systematically investigated. The results show that: when the pH value is 3.5 and 4.0, the coatings are mainly platelet-like calcium hydrogen phosphate (DCPA) (P1) at different FC, and FC has no remarkable effect on phase constitution of the coatings; when the pH value is 4.5 and 5.0, dandelion-like hydroxyapatite (HAP) (P6₃/m) are easily found at lower FC, and with the increase of FC, the coating changes from dandelion-like HAP to platelet-like DCPA; when the pH value is of 5.5 and 6.0, the coatings are mainly dandelion-like HAP at different FC, and with the increase of FC, the crystallinity of HAP increases, while with the increase of pH value, the diameter of dandelion-like HAP decreases. Otherwise, the wettability of the three typical coatings (i.e., the dandelion-like HAP, the platelet-like DCPA, and the mix of (HAP+DCPA)) show much better wettability than the titanium substrate, this indicates that the calcium-phosphate coatings would benefit the future osseointegration. Meanwhile, the formation mechanisms of different kinds of coatings were discussed.

Key words: calcium-phosphorus coating, hydroxyapatite, calcium hydrogen phosphate, hydrothermal method, filling condition, pH value, wettability

中图分类号:

O782⁺.1

邹梓杨, 吴松全, 杨义, 王皞, 黄爱军. 水热釜填充度与溶液pH值对水热法制备钙磷涂层的影响[J]. 人工晶体学报, 2023, 52(3): 526-535.

ZOU Ziyang, WU Songquan, YANG Yi, WANG Hao, HUANG Aijun. Effects of Filling Condition and pH Value on the Calcium-Phosphate Coatings Prepared via Hydrothermal Method[J]. JOURNAL OF SYNTHETIC CRYSTALS, 2023, 52(3): 526-535.

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