Construction of Drug Delivery System Based on SBA-15 Mesoporous Silica to Improve the Dissolution of Aniracetam

doi:10.16553/j.cnki.issn1000-985x.2025.0023

Abstract

Abstract: In order to improve the solubility and dissolution of insoluble drug aniracetam （ANI）， SBA-15 mesoporous silica carrier was prepared using P123 as template， and the pore-expanded L-SBA-15 carrier with enlarged pore size was obtained using 1，3，5-trimethylbenzene （TMB） as pore-expanding agent. ANI was loaded on two carriers， SBA-15 and L-SBA-15， to construct a drug delivery system based on SBA-15 mesoporous silica. The structure of carrier before and after drug loading was analyzed by SEM， TEM， FTIR， XRD and N₂ adsorption-desorption test. It is found that the pore sizes of SBA-15 and L-SBA-15 are 5.04 and 11.92 nm， and the drug loadings are 25.49% and 15.72%， respectively. Compare to the drug dissolution behavior in pH=1.2 and 6.8 dissolution media， it shows that both carriers can significantly improve the dissolution of ANI compared with ANI bulk drug， and the dissolution rate of ANI on L-SBA-15 carrier is slightly faster than that on SBA-15 carrier. This is related to the fact that ANI is highly dispersed in mesoporous materials and is physically adsorbed in mesoporous channels in an amorphous amorphous state， and larger mesopores are more conducive to the diffusion and dissolution of drugs. This study provides some certain experimental basis for improving the dissolution of insoluble drugs in order to increase the bioavailability of such drugs.

Key words: mesoporous silica; SBA-15; aniracetam; drug delivery system; dissolution; 1; 3; 5-trimethylbenzene

CLC Number:

MU Hanqing, LYU Jiangwei, WANG Pengguang, YU Keche, GAO Guangyu, ZHANG Wenjun. Construction of Drug Delivery System Based on SBA-15 Mesoporous Silica to Improve the Dissolution of Aniracetam[J]. Journal of Synthetic Crystals, 2025, 54(6): 1013-1020.

Figures/Tables 8

Fig.1 Preparation process flow chart of SBA-15 （a） and L-SBA-15 （b） carrier

Fig.2 SEM images of SBA-15 （a）， L-SBA-15 （b） and TEM images of SBA-15 （c）， L-SBA-15 （d）

Fig.3 FT-IR spectra of ANI， SBA-15， L-SBA-15， ANI/SBA-15 and ANI/L-SBA-15

Fig.4 Thermogravimetric curves of ANI， SBA-15， L-SBA-15， ANI/SBA-15， ANI/L-SBA-15 and related physical mixture

Fig.5 Small-angle XRD patterns of SBA-15， L-SBA-15， ANI/SBA-15 and ANI/L-SBA-15

Fig.6 Wide-angle XRD patterns of ANI， SBA-15， L-SBA-15， ANI/SBA-15 and ANI/L-SBA-15

Fig.7 N2 adsorption-desorption isotherm of SBA-15， ANI/SBA-15 （a） and L-SBA-15， ANI/L-SBA-15 （b）， and the corresponding pore size distribution （c）

Fig.8 Dissolution curves of ANI/SBA-15， ANI/L-SBA-15 and ANI in dissolution media of pH=1.2 （a） and pH=6.8 （b）

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